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BIO

 - GSK-3 inhibitor IX  - 6-Bromoindirubin-3'-oxime
Axon 1693
CAS:  667463-62-9
Purity:  98%
  • Soluble in DMSO
  • MF:  C16H10BrN3O2
  • MW:  356.17

Description

Potent, reversible, ATP-competitive and selective inhibitor of glycogen synthase kinase GSK-3 (IC50: 5 nM); Inhibition of GSK by BIO results in the activation of the Wnt signaling pathway and sustained pluripotency in human and murine embryonic stem cells (ESCs). BIO is shown to maintain self-renewal in human and murine ESCs

More Information

Parent CAS No. 667463-62-9
Chemical Name (Z)-6'-Bromo-1H,1'H-[2,3']biindolylidene-3,2'-dione 3-oxime
SMILES C1C=C2/C(=NO)/C(/NC2=CC=1)=C1C2C=CC(Br)=CC=2NC1=O
MFCD MFCD08705318
InChi InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+
InChiKey DDLZLOKCJHBUHD-WAVHTBQISA-N
CID 448949
Short Description GSK-3 inhibitor

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