LDN 193189 hydrochloride - DM 3189 hydrochloride

Based on 77 publications in PubMed 10 10 77

Axon 1509

CAS [1435934-00-1]

MF C25H22N6.2HCl
MW 479.40

  • Purity: 99%
  • Soluble in water and DMSO

LDN 193189 hydrochloride

Description

A highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; useful tool in stem cell biology. LDN 193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors.

*Promotion: LDN 193189 HCl is also part of Inhibitor Set(s):

Axon 5004 Axon 5005 Axon 5007


Prime Source Information:
The molecule of LDN 193189 contains multiple basic nitrogens, which could form 1-4 eq HCl salt of LDN 193189. This ligand from Axon is the best quality drug standard and its accurate salt form has been determined by microanalysis and specified on the certificate of analysis (COA) of every batch.

KEYWORDS: LDN 193189 hydrochloride | supplier | BMP inhibitor | DM 3189 HCl | LDN193189 | DM3189 | CAS [1435934-00-1] | [1062368-24-4] | [1062368-62-0] | TGF-β | BMP-ALK | Antagonist | RSTK | ALK2 | ALK3 | ALK6 | SMAD | stem cell biology | FOP | ectopic ossification | NSCLC

Order
Size Unit Price Stock
2 mg €70.00 In Stock
5 mg €95.00 In Stock
25 mg €335.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €560.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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