Fingolimod - FTY 720

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1485

CAS [162359-56-0]

MF C19H34ClNO2
MW 343.93

Purity: 98%
Soluble in DMSO

Fingolimod

Description

A sphingosine-1-phosphate receptor 1 modulator; immunosuppressant. FTY720 also activates the p21-activated kinase-1 (PAK1). Therefore, it could be a candidate therapeutic drug for the treatment of heart failure and arrhythmias.

EV Berdyshev et al. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. J. Biol. Chem. 2009, 284(9), 5467–77.

KK Dev et al. Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis. Pharmacol. Ther. 2008, 117, 77-93.

K Chiba et al. Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cell Mol. Immunol. 2006, 3, 11-19.

U Kunzendorf et al. FTY720—the first compound of a new promising class of immunosuppressive drugs. Nephrol. Dial. Transplant. 2004, 19, 1677-1681.

E.E. Egom et al. FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J. Mol. Cell. Cardiol. 2010, 48, 406-414.

W. Liu et al. A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin. Circ Heart Fail. 2013 Jul;6(4):833-44.

Angiogenesis Apoptosis Cardiovascular Immunology Miscellaneous Immunomodulator S1PR A13 PAK

S1PR1 agonist; Immunosuppressant

Chemical name

2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride

Parent CAS No.

[162359-55-9]

Order

Size	Unit Price	Stock
10 mg	€60.00	In Stock
50 mg	€150.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1672	SEW 2871	S1PR1 agonist	€80.00
1866	JTE 013	S1PR2 antagonist	€130.00
1947	RP 001 hydrochloride	A picomolar S1PR1 agonist	€110.00
2235	K 145 hydrochloride	Selective, substrate competitive SphK2 inhibitor	€105.00
1615	KRP203	S1PR1 agonist	€145.00
2367	AM 095 (parent compound)	Novel potent and selective LPA1 antagonist	€125.00
2377	Vidofludimus	Oral immunomodulatory drug that inhibits dihydroorotate dehydrogenase (DHODH)	€125.00
2350	PF 543 citrate	Cell-permeant reversible inhibitor of SphK1	€99.00
2404	TY 52156	Selective, competitive, and orally active S1P3 antagonist	€110.00
2331	FRAX 486	Bioavailable, brain penetrating inhibitor of p21-activated kinases (PAKs)	€90.00
2484	K6PC-5	SphK1 (or SK1) activator that increases sphingosine-1-phosphate production	€105.00
2565	N106	Activator of E1 ligase mediated SERCA2a SUMOylation	€95.00
2669	AZ13705339	Potent and selective PAK1 inhibitor	€125.00
2868	Roquinimex	Immunomodulator	€125.00
3096	Amiselimod hydrochloride	S1PR modulator	€105.00
3307	Pidotimod	Orally bioavailable immunostimulant	€50.00
3702	SLF1081851 hydrochloride	Spns2 inhibitor	€120.00
3961	PF-03758309	Potent and ATP-competitive inhibitor of p21-activated kinase (PAK4)	Inquire

Customer Support

Customer Services

About Axon Medchem

Contact Us

Fingolimod - FTY 720

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

Fingolimod - FTY 720

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us