Bulk Inquiry
Fingolimod
- FTY 720
- Parent CAS: 162359-55-9
- Soluble in DMSO
- MF: C19H34ClNO2
- MW: 343.93
Description
Fingolimod (FTY720) is a sphingosine-1-phosphate (S1P) receptor modulator that is phosphorylated in cells to an active metabolite with high affinity for S1P receptors, particularly S1P1. Sustained S1P1 engagement promotes receptor internalization and functional antagonism.
Loss of cell-surface S1P1 impairs lymphocyte egress from lymphoid tissues and produces the characteristic immunomodulatory action of fingolimod. The compound is an established tool for studying S1P receptor trafficking, immune-cell migration and neuroimmune signaling.
Key Features
- Prodrug converted to an active phosphorylated S1P receptor ligand
- Promotes S1P1 internalization and functional antagonism
- Restricts lymphocyte egress through modulation of S1P gradients
- Links sphingolipid receptor signaling to immune and CNS biology
Applications
- S1P receptor pharmacology and trafficking
- Lymphocyte migration and immune-cell sequestration studies
- Neuroinflammation and multiple sclerosis research
- Sphingolipid signaling and immunomodulator mechanism studies
More Information
| Parent CAS No. | 162359-55-9 |
|---|---|
| Chemical Name | 2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride |
| SMILES | C1(C=CC(CCC(CO)(CO)N)=CC=1)CCCCCCCC.Cl |
| MFCD | MFCD00939512 |
| InChi | InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H |
| InChiKey | SWZTYAVBMYWFGS-UHFFFAOYSA-N |
| CID | 107969 |
| Short Description | S1P agonist |
References
- EV Berdyshev et al. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. J. Biol. Chem. 2009, 284(9), 5467–77.
- KK Dev et al. Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis. Pharmacol. Ther. 2008, 117, 77-93.
- K Chiba et al. Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cell Mol. Immunol. 2006, 3, 11-19.
- U Kunzendorf et al. FTY720—the first compound of a new promising class of immunosuppressive drugs. Nephrol. Dial. Transplant. 2004, 19, 1677-1681.
- E.E. Egom et al. FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J. Mol. Cell. Cardiol. 2010, 48, 406-414.
- W. Liu et al. A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin. Circ Heart Fail. 2013 Jul;6(4):833-44.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1615 | KRP203 |
From $159.50 |
| 1672 | SEW 2871 |
From $88.00 |
| 1866 | JTE 013 |
From $143.00 |
| 1947 | RP 001 hydrochloride |
From $143.00 |
| 2235 | K 145 hydrochloride |
From $115.50 |
| 2331 | FRAX 486 |
From $99.00 |
| 2350 | PF 543 citrate |
From $108.90 |
| 2367 | AM 095 (parent compound) |
From $143.00 |
| 2377 | Vidofludimus |
From $137.50 |
| 2404 | TY 52156 |
From $121.00 |
| 2484 | K6PC-5 |
From $115.50 |
| 2565 | N106 |
From $104.50 |
| 2669 | AZ13705339 |
From $137.50 |
| 2868 | Roquinimex |
From $137.50 |
| 3096 | Amiselimod hydrochloride |
From $115.50 |
| 3307 | Pidotimod |
From $55.00 |
| 3702 | SLF1081851 hydrochloride |
From $132.00 |
| 3961 | PF-03758309 |
From Inquiry |
| 4360 | PF-543 hydrochloride |
From $99.00 |
