PF-03758309
- PF-3758309
Axon 3961
- Parent CAS: 898044-15-0
- Optical Purity: 99% e.e.
- Soluble in water and DMSO
- MF: C25H30N8OS.2HCl
- MW: 563.55
Description
PF-03758309 is a potent, orally bioavailable and ATP-competitive inhibitor of p21-activated kinase (PAK), a downstream effector of the Rho family functioning as a signaling node for various oncogenic pathways.
More Information
| Parent CAS No. | 898044-15-0 |
|---|---|
| Chemical Name | (S)-N-(2-(Dimethylamino)-1-phenylethyl)-6,6-dimethyl-3-(2-methylthieno[3,2-d]pyrimidin-4-ylamino)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C12SC=CC=1N=C(C)N=C2NC1=NNC2C(C)(C)N(C(=O)N[C@@H](C3C=CC=CC=3)CN(C)C)CC1=2.Cl.Cl |&1:22,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1 |
| InChiKey | AYCPARAPKDAOEN-LJQANCHMSA-N |
| CID | 25227462 |
| Short Description | PAK4 Inhibitor |
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