Istradefylline - KW6002

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1423

CAS [155270-99-8]

MF C20H24N4O4
MW 384.43

Purity: 99%
Soluble in DMSO

Istradefylline

Description

Very potent, selective and orally active adenosine A2A receptor antagonist in experimental models of Parkinson's disease

S Shiozaki et al. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl). 1999, 147(1), 90-95.

TN Chase et al. Translating A2A antagonist KW6002 from animal models to parkinsonian patients. Neurology 2003, 61(11 Suppl 6), S107-11.

PA LeWitt et al. Adenosine A2A receptor antagonist istradefylline (KW-6002) reduces "off" time in Parkinson's disease: a double-blind, randomized, multicenter clinical trial (6002-US-005). Ann. Neurol. 2008, 63(3), 295-302.

Adenosine A2A antagonist

Chemical name

(E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione

Parent CAS No.

[155270-99-8]

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5 mg	€75.00	In Stock
25 mg	€225.00	In Stock

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Istradefylline - KW6002

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Istradefylline - KW6002

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