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SD 169
- Soluble in DMSO and EtOH
- MF: C9H8N2O
- MW: 160.17
Description
ATP-competitive, orally active inhibitor of p38α MAP kinase (IC50 = 3.2 nM); being 38 fold selective vs against p38β MAP kinase (IC50 = 122 nM) and no inhibitory activity against a panel of other kinases including p38γ MAP kinase, ERK2, JNK-1 and MAPKAPK-2.
More Information
| Parent CAS No. | 1670-87-7 |
|---|---|
| Chemical Name | 1H-Indole-5-carboxylic acid amide |
| SMILES | C1(C(N)=O)C=C2C=CNC2=CC=1 |
| MFCD | MFCD07779486 |
| InChi | InChI=1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12) |
| InChiKey | GQMYQEAXTITUAE-UHFFFAOYSA-N |
| CID | 14973220 |
| Short Description | p38α MAPK inhibitor |
References
- S Medicherla et al. Preventive and Therapeutic Potential of p38α Selective MAPK Inhibitor in NOD Mice with Type 1 Diabetes. J. Pharmacol. Exp. Ther. 2006, 318, 99-107.
- Robert R. Myers et al. Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp. Neurol. 2003, 184(2), 606-614.
- J Yang et al. Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma. Leukemia, 2012, 26(9), 2114-2123.
- List of publications using SD 169 (Axon 1357) purchased from Axon Medchem
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