Bulk Inquiry
UK 432097
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C40H47N11O6
- MW: 777.87
Description
UK 432097 is a potent and selective adenosine A2A receptor agonist developed for chronic obstructive pulmonary disease research. Its high selectivity has also made it useful for detailed mapping of A2A receptor structure and function.
A2A adenosine receptors regulate cAMP signaling, inflammation, vascular responses and immune cell function. UK 432097 is a recommended tool for A2A receptor pharmacology, respiratory pathway research and receptor structure studies.
Key Features
- Potent and selective A2A adenosine receptor agonist
- Developed for COPD-related research
- Highly selective A2A receptor tool
- Useful for mapping A2A receptor structure-function relationships
Applications
- A2A receptor pharmacology
- Respiratory and COPD pathway research
- Purinergic cAMP signaling studies
- Adenosine receptor structure-function assays
More Information
| Parent CAS No. | 380221-63-6 |
|---|---|
| Chemical Name | 6-[(2,2-Diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-N-{2-[({[1-(2-pyridinyl)-4-piperidinyl]amino}carbonyl)amino]ethyl}-9H-purine-2-carboxamide |
| SMILES | C12N=C(C(=O)NCCNC(=O)NC3CCN(C4C=CC=CN=4)CC3)N=C(NCC(C3C=CC=CC=3)C3C=CC=CC=3)C=1N=C[N@@]2C1[C@H](O)[C@H](O)[C@@H](C(NCC)=O)O1 |&1:44,46,48,50,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C40H47N11O6/c1-2-41-37(54)33-31(52)32(53)39(57-33)51-24-46-30-34(45-23-28(25-11-5-3-6-12-25)26-13-7-4-8-14-26)48-35(49-36(30)51)38(55)43-19-20-44-40(56)47-27-16-21-50(22-17-27)29-15-9-10-18-42-29/h3-15,18,24,27-28,31-33,39,52-53H,2,16-17,19-23H2,1H3,(H,41,54)(H,43,55)(H2,44,47,56)(H,45,48,49)/t31-,32+,33-,39?/m0/s1 |
| InChiKey | ZOTHAEBAWXWVID-GHTJOHAJSA-N |
| CID | 91826456 |
| Short Description | A2A agonist |
References
- C. Russo et al. Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthma. Fundam. Clin. Pharmacol. 2006, 20, 9-19.
- Safety and efficacy of UK-432,097 in chronic obstructive pulmonary disease. ClinicalTrials.gov 2013.
- F. Xu et al. Structure of an Agonist-Bound Human A2A Adenosine Receptor. Science 2011, 332(6027), 322-327. (* UK432097 used in this study was procured from Axon Medchem.)
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1188 | Adenosine amine congener |
From $137.50 |
| 1190 | 2-Chloroadenosine |
From $71.50 |
| 1253 | SCH 58261 |
From $99.00 |
| 1264 | SCH 442416 |
From $99.00 |
| 1265 | SDZ-WAG 994 |
From $137.50 |
| 1287 | GR 79236 |
From $132.00 |
| 1319 | CGS 21680 hydrochloride |
From $104.50 |
| 1423 | Istradefylline |
From $82.50 |
| 1603 | Rolofylline |
From $99.00 |
| 1851 | Rolofylline metabolite M1-trans |
From $115.50 |
| 1852 | Rolofylline metabolite M1-cis |
From $115.50 |
| 2076 | MRS 1523 |
From $143.00 |
| 2283 | Desmethyl SCH 442416 |
From $330.00 |
| 2289 | ABT 702 |
From $143.00 |
| 2317 | BAY 60-6583 |
From $143.00 |
| 2583 | PXS 4728A |
From $170.50 |
| 3085 | CPI-444 |
From $93.50 |
| 3269 | PSB-KD107 |
From $154.00 |
| 3626 | Vipadenant |
From $99.00 |
| 3736 | CGS 15943 |
From $88.00 |
| 4001 | ZM241385 |
From $121.00 |
| 4069 | AZD4635 |
From Inquiry |
| 4132 | PBF-509 |
From $99.00 |
| 4377 | PSB-0777 ammonium salt |
From $165.00 |
