CHIR 98014 - CT 98014

Based on 132 reference(s) in Google Scholar 10 10 132

Axon 1126

CAS [252935-94-7]

MF C20H17Cl2N9O2
MW 486.31

Purity: 98%
Moderately soluble in DMSO

CHIR 98014

Description

Very potent, selective, cell-permeable reversible inhibitor of GSK-3; highly recommended tool.

ML Selenica et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br. J. Pharmacol. 2007, 152, 959–979.

SE Nikoulina et al. Inhibition of Glycogen Synthase Kinase 3 Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle. Diabetes 2002, 51(7), 2190-2198.

DB Ring et al. Selective glycogen synthase kinase inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 2003, 52, 588–595.

AS Wagman et al. Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes. Curr. Pharm. Des. 2004, 10, 1105–1137.

List of publications utilizing CHIR 98014 - CT98014 (Axon 1126) purchased from Axon Medchem

Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 Wnt-β-Catenin PI3K-Akt-mTOR EC 2.7.11.26

GSK-3 inhibitor

Chemical name

N*6*-{2-[4-(2,4-Dichloro-phenyl)-5-imidazol-1-yl-pyrimidin-2-ylamino]-ethyl}-3-nitro-pyridine-2,6-diamine

Parent CAS No.

[252935-94-7]

Order

Size	Unit Price	Stock
5 mg	€105.00	In Stock
25 mg	€365.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€160.00	In Stock
2 x 25 mg	€560.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1303	SB 216763	GSK-3 inhibitor	€85.00
1386	CHIR 99021	GSK-3 inhibitor	€65.00
1527	XAV 939	Tankyrase (TNKS) inhibitor	€80.00
1562	TWS 119	GSK-3β inhibitor	€70.00
1693	BIO	GSK-3 inhibitor	€95.00
1766	ICG 001	Specific inhibitor of Wnt/β-catenin signaling pathway	€115.00
1909	A 1070722	Selective inhibitor of GSK-3	€95.00
1922	JW 55	Inhibitor of tankyrase (TNKS 1 and 2)	€95.00
2010	TDZD 8	Selective and non-ATP-competitive inhibitor of GSK-3β	€90.00
2036	KY 02111	Canonical Wnt signaling pathway inhibitor	€80.00
2084	SKL 2001	Wnt/β-catenin signaling pathway agonist or activator	€90.00
2120	Wnt agonist 1	Wnt/β-catenin signaling pathway agonist or activator	€90.00
2133	iCRT5	β-Catenin-responsive transcription (CRT) inhibitor	€80.00
2167	AR-A 014418	ATP-competitive GSK-3 inhibitor	€85.00
2171	AZD 1080	Selective inhibitor of GSK-3α and GSK-3β	€110.00
2194	AZD 2858 hydrochloride	Potent and highly selective Glycogen Synthase Kinase-3β inhibitor	€95.00
2287	Wnt-C59	Highly potent porcupine (Porcn) inhibitor	€75.00
2435	CHIR 99021 dihydrochloride	GSK-3 inhibitor	€70.00
2135	iCRT14	Small-molecule inhibitor of the Wnt/wingless signaling pathway; CRT inhibitor	€135.00
2511	IM 12	GSK-3β inhibitor attenuating neuronal differentiation of human NPCs	€95.00
2859	J147	Potent and orally active neurotrophic drug	€90.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

CHIR 98014 - CT 98014

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

CHIR 98014 - CT 98014

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us