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Products
Enzymes
Transferases
Kinases (Serine-Threonine Specific Protein)
GSK-3
CHIR 98014

CHIR 98014 - CT 98014

Based on 132 reference(s) in Google Scholar 10 10 132

Axon 1126

CAS [252935-94-7]

MF C20H17Cl2N9O2
MW 486.31

Purity: 98%
Moderately soluble in DMSO

CHIR 98014

Description

Very potent, selective, cell-permeable reversible inhibitor of GSK-3; highly recommended tool.

KEYWORDS: CHIR 98014 | supplier | GSK-3 inhibitor | CT 98014 | CHIR98014 | CT98014 | CHIR-98014 | CT-98014 | CAS [252935-94-7] | glycogen synthase kinase | cell-permeable | reversible | CNS | Alzheimer | tau | phosphorylation | plaque

ML Selenica et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br. J. Pharmacol. 2007, 152, 959–979.

SE Nikoulina et al. Inhibition of Glycogen Synthase Kinase 3 Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle. Diabetes 2002, 51(7), 2190-2198.

DB Ring et al. Selective glycogen synthase kinase inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 2003, 52, 588–595.

AS Wagman et al. Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes. Curr. Pharm. Des. 2004, 10, 1105–1137.

List of publications utilizing CHIR 98014 - CT98014 (Axon 1126) purchased from Axon Medchem

Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 Wnt-β-Catenin PI3K-Akt-mTOR EC 2.7.11.26 Recent Price Changes

GSK-3 inhibitor

Chemical name

N*6*-{2-[4-(2,4-Dichloro-phenyl)-5-imidazol-1-yl-pyrimidin-2-ylamino]-ethyl}-3-nitro-pyridine-2,6-diamine

Parent CAS No.

[252935-94-7]

Order

Size	Unit Price	Stock
5 mg	€105.00	In Stock
25 mg	€365.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€160.00	In Stock
2 x 25 mg	€560.00	In Stock

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