GDC-0973
- Cobimetinib - RG7420 - XL518
- Optical Purity: >99% e.e.
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H21F3IN3O2
- MW: 531.31
Description
GDC-0973 is an orally bioavailable, potent and selective small-molecule inhibitor of mitogen-activated protein kinase 1 (MAP2K1 or MEK1). It blocks the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation, and decreased tumor cell proliferation. GDC-0976 is used, in combination with PLX4032 (Axon 1624), in the treatment of unresectable or metastatic melanoma with a BRAF V600E or V600K mutation.
More Information
| Parent CAS No. | 934660-93-2 |
|---|---|
| Chemical Name | (S)-(3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(NC2C=CC(I)=CC=2F)C(C(=O)N2CC(O)([C@H]3NCCCC3)C2)=CC=C(F)C=1F |&1:17,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | MEK1 inhibitor |
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