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AMG 900
- Soluble in DMSO
- MF: C28H21N7OS
- MW: 503.58
Description
More Information
| Parent CAS No. | 945595-80-2 |
|---|---|
| Chemical Name | N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine |
| SMILES | C1C=NC(OC2C=CC(NC3=NN=C(C4=CC(C)=CS4)C4C=CC=CC3=4)=CC=2)=C(C2C=CN=C(N)N=2)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C28H21N7OS/c1-17-15-24(37-16-17)25-20-5-2-3-6-21(20)26(35-34-25)32-18-8-10-19(11-9-18)36-27-22(7-4-13-30-27)23-12-14-31-28(29)33-23/h2-16H,1H3,(H,32,35)(H2,29,31,33) |
| InChiKey | IVUGFMLRJOCGAS-UHFFFAOYSA-N |
| CID | 24856041 |
| Short Description | Aurora inhibitor |
References
- MN Payton et al. Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 2010, 70(23), 9846-9854.
- L Huang et al. In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases. Xenobiotica. 2011, 41(5), 400-408.
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