Serabelisib
- MLN1117 - INK1117 - TAK-117
- Soluble in DMSO
- MF: C19H17N5O3
- MW: 363.37
Description
Serabelisib is an orally bioavailable, PI3K p110α-isoform specific inhibitor with an in vitro IC50 of 15 nM, highly selective against other isoforms (p110β, p110γ and p110δ) and mTOR (no significant inhibitions at 1 μM concentration). It displayed significant efficacy in several PI3Kα mutant-specific preclinical mouse xenograft tumor models, and blocked signaling to Akt and inhibited growth of cancer cells harboring wild-type or mutated p110α.
More Information
| Parent CAS No. | 1268454-23-4 |
|---|---|
| Chemical Name | (6-(2-Aminobenzo[d]oxazol-5-yl)imidazo[1,2-a]pyridin-3-yl)(morpholino)methanone |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(C2C=C3N=C(N)OC3=CC=2)=CN2C(C(=O)N3CCOCC3)=CN=C2C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H17N5O3/c20-19-22-14-9-12(1-3-16(14)27-19)13-2-4-17-21-10-15(24(17)11-13)18(25)23-5-7-26-8-6-23/h1-4,9-11H,5-8H2,(H2,20,22) |
| InChiKey | BLGWHBSBBJNKJO-UHFFFAOYSA-N |
| CID | 70798655 |
| Short Description | PI3K inhibitor |
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