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B591
- PI3K inhibitor B591
- Parent CAS: 1499285-30-1
- Soluble in DMSO
- MF: C25H24Br2N2O
- MW: 528.28
Description
B591 is a specific pan-PI3K inhibitor with potent inhibitory activity against class I PI3K isoforms (IC50 values of 1.300, 0.364, 0.107 and 1.580 μM for PI3Kα, PI3Kβ, PI3Kβγ, PI3Kδ, respectively), which showed effective inhibition of cellular PI3K/mTOR signaling pathway and robust antitumor activity in a set of cancer cell lines. Cancer stem cells (CSCs) targeting agent.
More Information
| Parent CAS No. | 1499285-30-1 |
|---|---|
| Chemical Name | 3-(2-Bromobenzyl)-1-((2,3-dihydrobenzofuran-5-yl)methyl)-5,6-dimethyl-1H-benzo[d]imidazol-3-ium bromide |
| SMILES | C1(C)C=C2[N+](CC3C(Br)=CC=CC=3)=CN(CC3C=CC4OCCC=4C=3)C2=CC=1C.[Br-] |
| MFCD | N.A. |
| InChi | InChI=1S/C25H24BrN2O.BrH/c1-17-11-23-24(12-18(17)2)28(15-21-5-3-4-6-22(21)26)16-27(23)14-19-7-8-25-20(13-19)9-10-29-25;/h3-8,11-13,16H,9-10,14-15H2,1-2H3;1H/q+1;/p-1 |
| InChiKey | SBYUBSHRIGQSPZ-UHFFFAOYSA-M |
| CID | 135799938 |
| Short Description | PI3K inhibitor |
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