Bulk Inquiry
PI 3065
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C27H31FN6OS
- MW: 506.64
Description
PI 3065 is a p110δ-selective PI3K inhibitor with Ki and IC50 values of 1.5 nM and 5 nM, respectively. Administration of PI 3065 suppressed 4T1 tumour growth and metastasis, to a similar extent as genetic inactivation of p110δ, marked by initial tumour progression, followed by tumour regression.
More Information
| Parent CAS No. | 955977-50-1 |
|---|---|
| Chemical Name | 4-(6-((4-(Cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine |
| SMILES | C1OCCN(C2=NC(C3C4C=CNC=4C=CC=3F)=NC3C=C(CN4CCN(CC5CC5)CC4)SC2=3)C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C27H31FN6OS/c28-21-3-4-22-20(5-6-29-22)24(21)26-30-23-15-19(17-33-9-7-32(8-10-33)16-18-1-2-18)36-25(23)27(31-26)34-11-13-35-14-12-34/h3-6,15,18,29H,1-2,7-14,16-17H2 |
| InChiKey | YDNOHCOYQVZOMC-UHFFFAOYSA-N |
| CID | 24937012 |
| Short Description | PI3K p110δ inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1281 | BEZ 235 |
From $55.00 |
| 1282 | BAG 956 |
From $104.50 |
| 1334 | PIK 75 hydrochloride |
From $77.00 |
| 1362 | PIK 90 |
From $93.50 |
| 1366 | LY 294002 |
From $77.00 |
| 1377 | GDC 0941 bismesylate |
From $88.00 |
| 1380 | PI 103 hydrochloride |
From $66.00 |
| 1417 | TGX 221 |
From $77.00 |
| 1424 | AS 252424 |
From $93.50 |
| 1436 | AS 252424 bispotassium salt |
From $104.50 |
| 1520 | NVP-BBD130 |
From $137.50 |
| 1596 | GSK 2126458 |
From $55.00 |
| 1706 | XL PI3K/mTOR inhibitor |
From $132.00 |
| 1719 | D 106669 |
From $93.50 |
| 1782 | GDC 0980 |
From $88.00 |
| 1797 | NVP-BKM120 |
From $99.00 |
| 1807 | PKI 587 |
From $99.00 |
| 1831 | A 66 |
From $104.50 |
| 1855 | PF 04691502 |
From $99.00 |
| 1912 | GSK 2636771 dihydrochloride |
From $115.50 |
| 2029 | NVP-BGT226 |
From $132.00 |
| 2039 | CZC 24832 |
From $104.50 |
| 2168 | IC 87114 |
From $93.50 |
| 2170 | CAL 101 |
From $104.50 |
