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Dorsomorphin
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C24H25N5O
- MW: 399.49
Description
Selective inhibitor of BMP signaling; functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation; Also a AMPK inhibitor (Ki value 109 nM)
* Note: The water-soluble form, Dorsomorphin dihydrochloride (Axon 2150) is also available.
More Information
| Parent CAS No. | 866405-64-3 |
|---|---|
| Chemical Name | 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine |
| SMILES | C12N=CC(=CN1N=CC=2C1C=CN=CC=1)C1=CC=C(C=C1)OCCN1CCCCC1 |
| MFCD | MFCD08705402 |
| InChi | InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 |
| InChiKey | XHBVYDAKJHETMP-UHFFFAOYSA-N |
| CID | 11524144 |
| Short Description | BMP inhibitor |
References
- PB Yu et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 2007, 4(1), 33-41.
- J Hao et al. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS ONE 2008, 3(8), e2904.
- JH Boergermann et al. Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Intl. J. Biochem. Cell Biol. 2010, 42(11), 1802-1807.
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