The mammalian target of rapamycin (mTOR; EC, a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to energy, nutrients, growth factors and other environmental cues, and it figures prominently in cancer. It belongs to the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family. mTOR assembles into two complexes with distinct inputs and downstream effects. mTOR complex 1 (mTORC1) is defined by its RAPTOR subunit which is replaced by RICTOR in mTOR complex (mTORC2).
mTORC1 regulates cell growth by promoting translation, ribosome biogenesis and autophagy. Its activation requires nutrients and amino acids, which result in the RAPTOR-mediated recruitment of mTORC1 to lysosomes and late endosomes, and co-localization with its activator, the small GTPase RHEB. mTORC1 substrates include the eIF4E-binding protein 1 (4E-BP1) and ribosomal S6 kinases (S6K).
mTORC2 responds primarily to growth factors, promoting cell-cycle entry, cell survival, actin cytoskeleton polarization and anabolic output. Its substrates include the Ser/Thr protein kinases Akt, SGK and PKC, which share the hydrophobic motif phosphorylation site with S6K1.
Noteworthy, rapamycin, which forms a ternary complex with the FK506-binding protein 12 (FKBP12) and the FRB domain of mTOR, is thought to be an allosteric inhibitor. Rapamycin–FKBP12 inhibits mTORC1 to a variable extent that is substrate and phosphorylation-site dependent, while it does not bind to mTORC2[1],[2].
Axon Ligands™ that block mTOR activity are also listed in the section for PI3K/AKT/mTOR signaling.

[1] mTOR kinase structure, mechanism and regulation. H. Yang et al. Nature 2013, 497, 217-223.
[2] mTOR: a protein kinase switching between life and death. L. Asnaghi, P. Bruno, M. Priulla, A. Nicolin. Pharmacol. Res. 2004, 50, 545-549.

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Axon ID Name Description From price
3996 AZD2014 Orally bioavailable dual mTORC1/mTORC2 inhibitor Inquire
1561 AZD8055 mTOR inhibitor €80.00
1281 BEZ 235 PI3K and mTOR tyrosine kinase inhibitor €50.00
2630 eCF309 Highly selective and potent inhibitor of mTOR signalling €85.00
4149 Everolimus Selective and orally active mTOR1 inhibitor Inquire
1782 GDC 0980 Dual PI3K and mTOR inhibitor €80.00
3584 GDC-0084 Brain-penetrant dual PI3K and mTOR inhibitor €110.00
1596 GSK 2126458 Dual PI3K and mTOR inhibitor €50.00
2142 INK 128 Potent and selective mTOR inhibitor €110.00
1472 KU-0063794 mTOR inhibitor €60.00
2425 MHY 1485 mTOR activator with an inhibitory effect on autophagy €70.00
3628 MHY-1685 mTOR inhibitor; Senescence inhibitor €50.00
2029 NVP-BGT226 Orally active dual PI3K/mTOR inhibitor €120.00
1718 Palomid 529 mTOR inhibitor €90.00
1855 PF 04691502 PI3K and mTOR tyrosine kinase inhibitor €90.00
1807 PKI 587 Dual PI3K and mTOR inhibitor €90.00
2069 Rapamycin Specific inhibitor of mTOR; binds to FKBP12 €85.00
5007 Stem Cell 5i inhibitor Set Set of five inhibitors for neural differentiation of human pluripotent stem cells. €200.00
1699 Temsirolimus mTOR inhibitor €95.00
1833 Torin 1 mTOR inhibitor €90.00
1834 Torin 2 mTOR inhibitor €90.00
3794 Urolithin A Inhibitor of the PI3K/AKT/mTOR pathway €70.00
2951 XL 388 Highly potent, selective, ATP-competitive, and orally bioavailable mTOR inhibitor €125.00
1706 XL PI3K/mTOR inhibitor Dual PI3K and mTOR kinase inhibitor €120.00
4009 XL-765 Potent and selective PI3K / mTOC inhibitor Inquire

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