Broad spectrum PKC inhibitor lacking inhibitory effect for the PKCμ isotype (IC50 values ranging from 7-60 nM for PKCα-PKCζ , and 20000 nM for PKCμ, respectively). Gö6983 significantly enhanced ERK1/2 activity not only in IL-6-stimulated cells, but also the basal ERK1/2 activity in non-stimulated cells; yet, it has no effect on IL-6-triggered B9 cell proliferation, suggesting a crucial role for PKCμ. Useful tool for isolation, generation, derivatization and stabilization of naive human pluripotent stem cells in so called NHSM conditions developed at the Weizmann Institute of Science.

*Promotion: Gö 6983 is also part of Inhibitor Set(s):

KEYWORDS: GO 6983 | supplier | PKC inhibitor | GO6983 | Gö 6983 | Gö6983 | GO6983 | CAS [133053-19-7] | PKCμ | Inhibitor | MAPK | ERK | ischemia | reperfusion | IL-6 | proliferation  | naïve | pluripotent | stem cells