Stem Cell Differentiator

Cell differentiationAll cells within a complex multicellular organism contain the same set of DNA. Different deployment of the eukaryotic genome by epigenetic modulation such as methylation and acetylation determines different cellular morphology and function. This process of gene expression is regulated by cues from both within and outside cells. Since epigenetic mechanisms are intrinsically reversible, interdependent, and highly dynamic, they provide the opportunity to differentiate cells in a controlled manor[1]. The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming. Recent advances have shown that the addition of a group of genes can not only restore pluripotency in a fully differentiated cell state (reprogramming) but can also induce the cell to proliferate (dedifferentiation) or even switch to another cell type (transdifferentiation). Current research aims to understand how these processes work and to eventually harness them for use in regenerative medicine[2].
Products listed below are known for their specific ability to effectuate differentiation of stem cells. Many more Axon Ligands™ useful in the field of stem cell research can be found in the corresponding product class of stem cell research products and stem cell inhibitor sets.

[1] A. Ralston et al. Gene Expression Regulates Cell Differentiation. Nat. Education 2008, 1(1):127
[2] From: C. Jopling et al. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat. Rev. Mol. Cell Biol. 2011, 12, 79-89.

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Axon ID Name Description From price
1313 1-EBIO K+ channel opener (Ca2+ activated) €50.00
2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase €80.00
2122 AGI 5198 Inhibitor of R132 mutant isocitrate dehydrogenase 1 (IDH1) €60.00
2274 AGI 6780 Potent and selective inhibitor of the tumor-associated mutant IDH2 (R140Q) €90.00
2550 Cardiogenol C hydrochloride Stem cell differentiator; inducer of the differentiation of ESCs to cardiomyocytes €90.00
1950 CDDO A potent multifunctional anti-tumor agent. PPAR-γ agonist €80.00
1484 DAPT γ-Secretase inhibitor €90.00
1708 Dorsomorphin Inhibitor of BMP signaling. Inhibits ALK2, 3 and 6 €65.00
1872 Eltrombopag Thrombopoietin receptor (TpoR or c-MPL) agonist €95.00
2227 EPZ 6438 Inhibitor of Histone Lysine Methyltransferase EZH2 €90.00
2320 FH 1 Promotes the maturation and differentiation of iPSCs to hepatocytes €50.00
2264 Forskolin Activator of adenylate cyclase. Naturally occurring labdane diterpene €90.00
2355 FPH 2 Proliferation inducer of mature human primary hepatocytes €110.00
2466 Gö 6983 Broad spectrum PKC inhibitor lacking inhibitory effect for PKCμ €90.00
2323 ITD 1 Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis €105.00
2378 Kartogenin Promotor of chondrocyte differentiation from primary human MSCs €75.00
2871 ML 239 Selective inhibitor of breast cancer stem cells €95.00
2322 Neuropathiazol Selective inducer of neural differentiation of adult hippocampal neural progenitor cells (NPCs). €135.00
1673 PD173074 FGFR1 and FGFR3 inhibitor €75.00
1871 Pifithrin-α hydrobromide Inhibitor of p53 protein €95.00
2091 PluriSIn #1 Inhibitor of stearoyl-coA desaturase (SCD1) €75.00
1690 Purmorphamine Hedgehog signaling pathway activator €120.00
1801 Pyroxamide HDAC1 Inhibitor €90.00
1629 Reversine MPS1 kinase inhibitor €85.00
2084 SKL 2001 Wnt/β-catenin signaling pathway agonist or activator €90.00
2627 SMER 28 Small molecule enhancer of rapamycin that enhances autophagy €80.00
2209 Sodium butyrate Noncompetitive inhibitor of multiple histone deacetylases (HDACs) €50.00
5007 Stem Cell 5i inhibitor Set Set of five inhibitors for neural differentiation of human pluripotent stem cells. €200.00
5006 Stem Cell CSD inhibitor Set Set of CHIR99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. €140.00
5004 Stem Cell LSB inhibitor Set Set of BMP inhibitor LDN 193189 (Axon 1509) and TGF-β inhibitor SB 431542 (Axon 1661) €90.00

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