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LY 333531 hydrochloride
- Ruboxistaurin
- Parent CAS: 169939-94-0
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C28H28N4O3.HCl
- MW: 505.01
Description
Orally active protein kinase C β (PKC-β) specific inhibitor; the more water soluble mesylate salt of LY 333531 (Axon 1401) is available as well.
More Information
| Parent CAS No. | 169939-94-0 |
|---|---|
| Chemical Name | 13-((Dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(e,k)pyrrolo(3,4-h)(1,4,13) oxadiazacyclohexadecene-1,3(2H)-dione hydrochloride |
| SMILES | C12C3=CN(CCO[C@H](CN(C)C)CCN4C5C=CC=CC=5C(=C4)C=1C(=O)NC2=O)C1C=CC=CC3=1.Cl |&1:7,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1 |
| InChiKey | NYQIEYDJYFVLPO-FERBBOLQSA-N |
| CID | 9870785 |
| Short Description | PKC-β inhibitor |
References
- Ruboxistaurin: LY 333531. Drug R. D. 2007, 8(3), 193-199.
- LY-333531 mesylate hydrate. Drugs Fut. 2000, 25(10), 1017.
- GL Engel et al. Salt form selection and characterization of LY333531 mesylate monohydrate. Int. J. Pharmaceutics 2000, 198(2), 239-247.
- MR Jirousek et al. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacy clohexadecene-1,3(2H)-dione (LY333531) and related analogues.... J. Med. Chem. 1996, 39, 2664.
- Y Wu et al. Protein kinase C beta inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats. J. Pharmacol. Sci. 2006, 101(4), 335-343.
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