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LY 333531 mesylate
- Ruboxistaurin
- Parent CAS: 169939-94-0
- Soluble in DMSO
- MF: C28H28N4O3.CH4O3S
- MW: 564.65
Description
Orally active protein kinase C β (PKC-β) specific inhibitor; a salt form that is five times more water-soluble than its hydrochloride salt.
The hydrochloride salt of LY 333531 (Axon 2362) is available as well.
More Information
| Parent CAS No. | 169939-94-0 |
|---|---|
| Chemical Name | 13-((Dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21 -dimetheno-1H,13H-dibenzo(e,k)pyrrolo(3,4-h)(1,4,13) oxadiazacyclohexadecene-1,3(2H)-dione methanesulfonate |
| MFCD | MFCD09970504 |
| Short Description | PKC-β inhibitor |
References
- Ruboxistaurin: LY 333531. Drug R. D. 2007, 8(3), 193-199.
- LY-333531 mesylate hydrate. Drugs Fut. 2000, 25(10), 1017.
- GL Engel et al. Salt form selection and characterization of LY333531 mesylate monohydrate. Int. J. Pharmaceutics 2000, 198(2), 239-247.
- MR Jirousek et al. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacy clohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. J. Med. Chem. 1996, 39, 2664.
- Y Wu et al. Protein kinase C beta inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats. J. Pharmacol. Sci. 2006, 101(4), 335-343.
- List of publications using LY 333531 (Axon 1401) purchased from Axon Medchem
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