Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3211

CAS [2222094-18-8]

MF C24H24F3NO2
MW 415.45

  • Purity: 99%
  • Soluble in DMSO and EtOH



BC1618 is a potent, orally bioavailable, and metabolically stable Fbxo48 inhibitor and Ampk activator. Specifically, BC1618 increases the biological activity of Ampk not by stimulating the activation of Ampk, but rather by preventing activated pAmpkα from Fbxo48-mediated degradation. BC1618 promotes mitochondrial fission, facilitates autophagy, and improves hepatic insulin sensitivity in high fat diet-induced obese mice.

KEYWORDS: BC1618 | Supplier | Fbxo48 inhibitor | BC 1618 | BC-1618 | CAS [2222094-18-8] | phosphorylated Ampk α (pAmpkα) | Ubiquitin Ligase (E3; other) | Inhibitor | Enzymes

Size Unit Price Stock
10 mg €120.00 In Stock
50 mg €420.00 In Stock
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Size Unit Price Stock
2 x 10 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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