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CID 755673
- Soluble in DMSO
- MF: C12H11NO3
- MW: 217.22
Description
CID 755673 is a selective inhibitor of protein kinase D (PKD) family signaling.
PKD kinases integrate diacylglycerol and PKC-linked signals to regulate vesicle trafficking, gene expression, cell motility and survival. CID 755673 is useful for probing PKD-dependent cellular responses and kinase pathway selectivity.
Key Features
- Selective inhibitor of protein kinase D signaling
- Targets PKD-dependent downstream signaling pathways
- Useful for studying cell motility and trafficking responses
- Tool compound for PKD family kinase pharmacology
Applications
- Protein kinase D assays
- DAG/PKC downstream signaling research
- Cell migration and invasion models
- Cancer and secretory pathway studies
More Information
| Parent CAS No. | 521937-07-5 |
|---|---|
| Chemical Name | 7-hydroxy-2,3,4,5-tetrahydro-1H-benzofuro[2,3-c]azepin-1-one |
| SMILES | OC1=CC=C2OC3C(NCCCC=3C2=C1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15) |
| InChiKey | AACFPJSJOWQNBN-UHFFFAOYSA-N |
| CID | 755673 |
| Short Description | PKD inhibitor |
References
- ER Sharlow et al. Potent and Selective Disruption of Protein Kinase D Functionality by a Benzoxoloazepinolone. J. Biol. Chem. 2008, 283, 33516-33526.
- E Torres-Marquez et al. CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway. Biochem. Biophys. Res. Commun. 2010, 391(1), 63-68.
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