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B106
- BJE6-106
- Soluble in DMSO
- MF: C26H23NO2
- MW: 381.47
Description
B106 is a potent and selective PKC-δ inhibitor with an IC50 value for PKC-δ of <0.05 µM and targeted selectivity over classical PKC isozymes (a 1000-fold PKC-δ selectivity over PKC-α). B106 efficiently induced apoptosis in several cell lines.
More Information
| Parent CAS No. | 1564249-38-2 |
|---|---|
| Chemical Name | 6-(2-(9H-Carbazol-9-yl)ethyl)-2,2-dimethyl-2H-chromene-8-carbaldehyde |
| SMILES | C1C(CCN2C3C=CC=CC=3C3C=CC=CC2=3)=CC(C=O)=C2OC(C)(C)C=CC=12 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H23NO2/c1-26(2)13-11-19-15-18(16-20(17-28)25(19)29-26)12-14-27-23-9-5-3-7-21(23)22-8-4-6-10-24(22)27/h3-11,13,15-17H,12,14H2,1-2H3 |
| InChiKey | QLDDENZBVHBRKN-UHFFFAOYSA-N |
| CID | 85471521 |
| Short Description | PKC-δ inhibitor |
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