Celecoxib - SC 58635 | Celebrex | Celebra

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1919

CAS [169590-42-5]

MF C17H14F3N3O2S
MW 381.37

Purity: 99%
Soluble in DMSO

Celecoxib

Description

Selective cyclooxygenase-2 (COX-2) inhibitor (IC50: 15 and 0.04 μM for COX-1 and COX-2 respectively); inhibition of COX-2 inhibits only prostaglandin synthesis without affecting thromboxane (TXA2) and thus offers no cardioprotective effects of NSAIDs, which inhibits both COX-1 and COX-2 non-selectively.

TD Penning et al. Synthesis and Biological Evaluation of the 1.5 Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-(...). J. Med. Chem. 1997, 40 (9), 1347–1365.

DL DeWitt. Cox-2-selective inhibitors: the new super aspirins. Mol. Pharmacol. 1999, 55(4), 625-631.

Selective COX-2 inhibitor

Chemical name

4-(5-p-tolyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Parent CAS No.

[169590-42-5]

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Celecoxib - SC 58635 | Celebrex | Celebra

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Description

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Parent CAS No.

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