ABT 102

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1504

CAS [808756-71-0]

MF C21H24N4O
MW 348.44

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

ABT 102

Description

Potent and selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptors (IC50 values to be 5-7 nM) under clinical trials; TRVP1 receptor antagonism is a promising approach for pain management

CS Surowy et al. ABT-102 Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo. JPET 2008, 326(3), 879-888.

P Honore et al. Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. Pain. 2009, 142(1-2), 27-35.

TRPV1 antagonist

Chemical name

(R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea

Parent CAS No.

[808756-71-0]

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ABT 102

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ABT 102

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