Your cart

There are no items in your shopping cart

RQ 00203078

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2498

CAS [1254205-52-1]

MF C21H13ClF6N2O5S
MW 554.85

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO

RQ 00203078

Description

Selective, potent, and orally active TRPM8 antagonist (IC50 value 8.3 nM) that demonstrated excellent in vivo activity in a dose dependent manner with an ED50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration.
Selective, potent, and orally active TRPM8 antagonist with in vivo activity

Chemical name

4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid

Parent CAS No.

[1254205-52-1]

Order
Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €450.00 In Stock
Need more? Bulk Inquiry

Related Products

Axon ID Name Description From price
1225 U 73122 PLC inhibitor €95.00
1504 ABT 102 TRPV1 antagonist €90.00
1816 A 784168 TRPV1 receptor antagonist €95.00
2374 Optovin Reversible photoactivated TRPA1 agonist €85.00
2423 M8-B hydrochloride Selective and potent antagonist of the TRPM8 channel €115.00
2742 GSK 2193874 Orally active TRPV4 antagonist €120.00
3348 NMDAR-TRPM4 blocker C8 dihydrochloride NMDAR/TRPM4 interaction interface inhibitor €120.00
3349 NMDAR-TRPM4 blocker C19 dihydrochloride NMDAR/TRPM4 interaction interface inhibitor €130.00
3633 Ononetin Potent and selective TRPM3 antagonist €60.00

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Newsletter
Give Feedback
 
Send E-mail

Customer Support

About Axon Medchem

Download Product Catalog

Download the Axon Ligands™ catalogue 2021 Spring Edition

Follow Us

© 2016 Axon Medchem. All Rights Reserved.

Send us a message

×

Contact Us

* Required Fields

Please wait...