RQ 00203078

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2498

CAS [1254205-52-1]

MF C21H13ClF6N2O5S
MW 554.85

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO

RQ 00203078


Selective, potent, and orally active TRPM8 antagonist (IC50 value 8.3 nM) that demonstrated excellent in vivo activity in a dose dependent manner with an ED50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration.
Selective, potent, and orally active TRPM8 antagonist with in vivo activity

Chemical name

4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid

Parent CAS No.


Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €450.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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