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PF 05105679
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C26H21FN2O3
- MW: 428.45
Description
TRPM8 inhibitor (IC50 value 0.1 μM for TRPM8 in single cell patch clamp electrophysiology (Ephys) studies), showing >100-fold selectivity across a range of different receptors, ion channels, and enzymes including the closely related TRPV1 and TRPA1 channels. Although PF-05105679 shows no effect on core body temperature in humans, it proofs to be a useful tool to study in vitro effects of TRPM8 on thermoregulation and for the treatment of pain in humans.
More Information
| Parent CAS No. | 1398583-31-7 |
|---|---|
| Chemical Name | (R)-3-((N-(1-(4-fluorophenyl)ethyl)quinoline-3-carboxamido)methyl)benzoic acid |
| SMILES | C(O)(=O)C1=CC=CC(CN([C@@H](C2=CC=C(F)C=C2)C)C(C2=CC3C(N=C2)=CC=CC=3)=O)=C1 |&1:10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C26H21FN2O3/c1-17(19-9-11-23(27)12-10-19)29(16-18-5-4-7-21(13-18)26(31)32)25(30)22-14-20-6-2-3-8-24(20)28-15-22/h2-15,17H,16H2,1H3,(H,31,32)/t17-/m1/s1 |
| InChiKey | BXNMZRPTQFVRFA-QGZVFWFLSA-N |
| CID | 60195662 |
| Short Description | TRPM8 antagonist |
References
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