TRPM8 inhibitor (IC50 value 0.1 μM for TRPM8 in single cell patch clamp electrophysiology (Ephys) studies), showing >100-fold selectivity across a range of different receptors, ion channels, and enzymes including the closely related TRPV1 and TRPA1 channels. Although PF-05105679 shows no effect on core body temperature in humans, it proofs to be a useful tool to study in vitro effects of TRPM8 on thermoregulation and for the treatment of pain in humans.

KEYWORDS: PF 05105679 | supplier | TRPM8 antagonist | PF05105679 | PF5105679 | CAS [1398583-31-7] | TRPM8 | Blocker | Ion Channels | transient receptor potential | TRP | cold | pain | analgesic | thermoregulation | melastatin | hypothermia