PF 05105679

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2483

CAS [1398583-31-7]

MF C26H21FN2O3
MW 428.45

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

PF 05105679

Description

TRPM8 inhibitor (IC50 value 0.1 μM for TRPM8 in single cell patch clamp electrophysiology (Ephys) studies), showing >100-fold selectivity across a range of different receptors, ion channels, and enzymes including the closely related TRPV1 and TRPA1 channels. Although PF-05105679 shows no effect on core body temperature in humans, it proofs to be a useful tool to study in vitro effects of TRPM8 on thermoregulation and for the treatment of pain in humans.

KEYWORDS: PF 05105679 | supplier | TRPM8 antagonist | PF05105679 | PF5105679 | CAS [1398583-31-7] | TRPM8 | Blocker | Ion Channels | transient receptor potential | TRP | cold | pain | analgesic | thermoregulation | melastatin | hypothermia

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Size Unit Price Stock
5 mg €90.00 In Stock
25 mg €310.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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