M8-B hydrochloride

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2423

CAS [883976-12-3]

MF C22H24N2O3S.HCl
MW 432.96

  • Purity: 99%
  • Soluble in water and DMSO

M8-B hydrochloride


Selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel with in vitro and in vivo activity. M8-B blocked cold-induced and TRPM8-agonist-induced activation of TRPM8 channels (IC50 values 7.8 nM, 26.9 nM, and 64.3 nM following activation by cold, icilin or menthol, respectively), and decreased deep body temperature in mice and rats in vivo. M8-B did not block other TRP channels (IC50 > 20 μM).
Size Unit Price Stock
10 mg €115.00 In Stock
50 mg €415.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...