Your cart

There are no items in your shopping cart

M8-B hydrochloride

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2423

CAS [883976-12-3]

MF C22H24N2O3S.HCl
MW 432.96

  • Purity: 99%
  • Soluble in water and DMSO

M8-B hydrochloride

Description

Selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel with in vitro and in vivo activity. M8-B blocked cold-induced and TRPM8-agonist-induced activation of TRPM8 channels (IC50 values 7.8 nM, 26.9 nM, and 64.3 nM following activation by cold, icilin or menthol, respectively), and decreased deep body temperature in mice and rats in vivo. M8-B did not block other TRP channels (IC50 > 20 μM).
Order
Size Unit Price Stock
10 mg €115.00 In Stock
50 mg €415.00 In Stock
Need more? Bulk Inquiry

Related Products

Axon ID Name Description From price
1225 U 73122 PLC inhibitor €95.00
1504 ABT 102 TRPV1 antagonist €90.00
1816 A 784168 TRPV1 receptor antagonist €95.00
2374 Optovin Reversible photoactivated TRPA1 agonist €85.00
2458 Clemizole Inhibitor of the transient receptor potential channel TRPC5 €75.00
2498 RQ 00203078 Selective, potent, and orally active TRPM8 antagonist with in vivo activity €125.00
2483 PF 05105679 TRPM8 inhibitor with >100-fold selectivity and in vivo activity in humans €95.00
2742 GSK 2193874 Orally active TRPV4 antagonist €120.00
3348 NMDAR-TRPM4 blocker C8 dihydrochloride NMDAR/TRPM4 interaction interface inhibitor €120.00
3349 NMDAR-TRPM4 blocker C19 dihydrochloride NMDAR/TRPM4 interaction interface inhibitor €130.00
3633 Ononetin Potent and selective TRPM3 antagonist €60.00

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Newsletter
Give Feedback
 
Send E-mail

Customer Support

About Axon Medchem

Download Product Catalog

Download the Axon Ligands™ catalogue 2021 Spring Edition

Follow Us

© 2016 Axon Medchem. All Rights Reserved.

Send us a message

×

Contact Us

* Required Fields

Please wait...