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M8-B hydrochloride

Axon 2423
  • Parent CAS:  884049-35-8
Purity:  99%
  • Soluble in water and DMSO
  • MF:  C22H24N2O3S.HCl
  • MW:  432.96

Description

Selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel with in vitro and in vivo activity. M8-B blocked cold-induced and TRPM8-agonist-induced activation of TRPM8 channels (IC50 values 7.8 nM, 26.9 nM, and 64.3 nM following activation by cold, icilin or menthol, respectively), and decreased deep body temperature in mice and rats in vivo. M8-B did not block other TRP channels (IC50 > 20 μM).

More Information

Parent CAS No. 884049-35-8
Chemical Name N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride
SMILES C1(C(N(CCN)CC2=CC=C(OCC3=CC=CC=C3)C(OC)=C2)=O)SC=CC=1.Cl
MFCD N.A.
InChi InChI=1S/C22H24N2O3S.ClH/c1-26-20-14-18(9-10-19(20)27-16-17-6-3-2-4-7-17)15-24(12-11-23)22(25)21-8-5-13-28-21;/h2-10,13-14H,11-12,15-16,23H2,1H3;1H
InChiKey FMQJBHACRTZLME-UHFFFAOYSA-N
CID 69316632
Short Description TRPM8 antagonist

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