Bulk Inquiry
A 784168
- Soluble in DMSO
- MF: C19H15F6N3O3S
- MW: 479.4
Description
A 784168 is a potent and selective transient receptor potential vanilloid 1 (TRPV1) antagonist with a reported IC50 value of 24 nM.
TRPV1 is a heat-, proton- and vanilloid-sensitive ion channel that contributes to inflammatory and neuropathic pain signaling in sensory neurons. A 784168 is used to study TRPV1-dependent nociception and analgesic mechanisms.
Key Features
- Potent TRPV1 antagonist
- Reported IC50: 24 nM
- Blocks vanilloid receptor signaling in sensory pathways
- Demonstrates antinociceptive activity in pain models
Applications
- TRPV1 channel pharmacology
- Pain and nociception research
- Sensory-neuron calcium signaling assays
- Inflammatory and neuropathic pain model studies
More Information
| Parent CAS No. | 824982-41-4 |
|---|---|
| Chemical Name | 1-(3-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethylsulfonyl)phenyl)-1,2,3,6-tetrahydropyridine-4-carboxamide |
| SMILES | C1N(C2=NC=CC=C2C(F)(F)F)CC=C(C(NC2=CC=C(S(C(F)(F)F)(=O)=O)C=C2)=O)C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H15F6N3O3S/c20-18(21,22)15-2-1-9-26-16(15)28-10-7-12(8-11-28)17(29)27-13-3-5-14(6-4-13)32(30,31)19(23,24)25/h1-7,9H,8,10-11H2,(H,27,29) |
| InChiKey | SDUAWRFBHRAFBM-UHFFFAOYSA-N |
| CID | 11420211 |
| Short Description | TRPV1 antagonist |
References
- M Cui et al. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J. Neurosci. 2006, 26(37), 9385-9393.
- SB Brown et al. Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists. Bioorg. Med. Chem. 2008, 16, 8516–8525.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1504 | ABT 102 |
From $99.00 |
| 2374 | Optovin |
From $93.50 |
| 2423 | M8-B hydrochloride |
From $132.00 |
| 2458 | Clemizole |
From $82.50 |
| 2483 | PF 05105679 |
From $121.00 |
| 2498 | RQ 00203078 |
From $143.00 |
| 2742 | GSK 2193874 |
From $132.00 |
| 3287 | SET2 |
From $110.00 |
| 3348 | NMDAR-TRPM4 blocker C8 dihydrochloride |
From $132.00 |
| 3349 | NMDAR-TRPM4 blocker C19 dihydrochloride |
From $143.00 |
| 3356 | AMG 9810 |
From $99.00 |
| 3633 | Ononetin |
From $66.00 |
| 4226 | TRPV1 antagonist CX-3 |
From $99.00 |
| 4367 | BCTC |
From $132.00 |
