A 784168

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1816

CAS [824982-41-4]

MF C19H15F6N3O3S
MW 479.40

Purity: 98%
Soluble in DMSO

A 784168

Description

Potent and selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptors (IC50: 24 nM); displayed potent anti-nociceptive effects in a broad range of animal pain models upon oral dosing. This analgesic activity results from its ability to penetrate the central nervous system

M Cui et al. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J. Neurosci. 2006, 26(37), 9385-9393.

SB Brown et al. Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists. Bioorg. Med. Chem. 2008, 16, 8516–8525.

TRPV1 receptor antagonist

Chemical name

1-(3-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethylsulfonyl)phenyl)-1,2,3,6-tetrahydropyridine-4-carboxamide

Parent CAS No.

[824982-41-4]

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5 mg	€95.00	In Stock
25 mg	€335.00	In Stock

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A 784168

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A 784168

Description

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