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Axon 2742
CAS [1336960-13-4]
MF C37H38BrF3N4OMW 691.62
GSK 2193874 is a potent, selective, and orally active TRPV4 channel blocker (IC50 values of 2 and 40 nM for rTRPV4 and hTRPV4, respectively). TRPV4 blockade with GSK 2193874 provided protection against the development of pulmonary edema and the resulting deficits in arterial oxygenation in heart failure models in vivo.
KEYWORDS: GSK 2193874,supplier,TRPV4 antagonist,GSK2193874,GSK-2193874,CAS [1336960-13-4],Non Selective (Cations),TRPV4,Antagonist,Ion Channels,Pulmonary Edema
3-(1,4'-Bipiperidin-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-(3-(trifluoromethyl)phenyl)quinoline-4-carboxamide
[1336960-13-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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