Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2458

CAS [442-52-4]

MF C19H20ClN3
MW 325.84

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO



Inhibitor of the transient receptor potential channel TRPC5 with selectivity over other TRCP channels (IC50 values 9.1 µM, 6.4 µM, 1-1.3 µM, 11.3 µM, and 26.5 µM for TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7). Only weakly affected TRPM3 and TRPM8, and TRPV1-4 at markedly higher concentrations of Clemizole. Clemizole was originally developed as antihistaminergic drug and found to inhibit monoamine reuptake in the brain. Clemizole was also found to exhibit antiviral activity by inhibition of NS4B binding to RNA in HCV.
Size Unit Price Stock
10 mg €75.00 In Stock
50 mg €255.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...