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Clemizole
- NSC 46261
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C19H20ClN3
- MW: 325.84
Description
More Information
| Parent CAS No. | 442-52-4 |
|---|---|
| Chemical Name | 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole |
| SMILES | C1(CN2CCCC2)N(CC2=CC=C(Cl)C=C2)C2=CC=CC=C2N=1 |
| MFCD | MFCD00051435 |
| InChi | InChI=1S/C19H20ClN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2 |
| InChiKey | CJXAEXPPLWQRFR-UHFFFAOYSA-N |
| CID | 2782 |
| Short Description | TRPC5 blocker |
References
- J.M. Richter et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21.
- T. Nguyen et al. Discovery of a novel member of the histamine receptor family. Mol Pharmacol. 2001 Mar;59(3):427-33.
- S. Einav et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74.
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