AMG 9810 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with antihyperalgesic properties (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM). Also, AMG 9810 blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine.

KEYWORDS: AMG 9810 | supplier | TRPV1 antagonist | AMG9810 | AMG-9810 | CAS [545395-94-6] | Non Selective (Cations) | TRPV1 | Antagonist | Ion Channels | Hyperalgesia