Stem Cells
Special attention is offered to the class of Axon Ligands™ that finds its application (among other applications in most cases) in stem cell research projects. The medical use of stem cells, cells with the ability to perpetuate themselves through self-renewal and to differentiate into a particular cell type through differentiation, is receiving extensive interest as they might regenerate damaged tissue under the right conditions[1]. This unique capacity could serve patients suffering from organ malfunction, cell deficiency, and/or neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease by replacing affected/deficient cells with healthy new cells[2]. We have selected several combinations of Axon Ligands™ that have been used frequently as a combined set for epigenetic research. These sets include, for example inhibitors of GSK3, FGFR, MEK, SRC, etc.
Compound libraries of Axon Ligands™ can generally be offered with bulk discount . All Axon Ligands™ in the libraries are individually identified and analyzed to meet the strong requirements to pass our QC for drug standards.
[1] Stem cells, cancer, and cancer stem cells. Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, Irving L. Weissman. Nature, Vol 414, 2001, 105.
[2] Embryonic stem cells in drug discovery. J. McNeish. Nature Rev. Drug Disc. 2004, 3, 70.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
5011 | Naive Stem Cell 5i inhibitor Set | Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency | €200.00 | |
5010 | Naive Stem Cell NHSM inhibitor Set | Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs | €230.00 | |
2128 | Stem Cell 2i inhibitor Set | Set of MEK inhibitor PD0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €90.00 | |
2129 | Stem Cell 3i inhibitor Set | Set of FGFR inhibitor SU5402 (Axon 1667), MEK inhibitor PD184352 (Axon 1368) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €130.00 | |
5009 | Stem Cell 4i inhibitor Set | Set of Thiazovivin, SB 431542, PD0325901, and CHIR99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) | €170.00 | |
5007 | Stem Cell 5i inhibitor Set | Set of five inhibitors for neural differentiation of human pluripotent stem cells. | €200.00 | |
2130 | Stem Cell Alternative 2i inhibitor Set | Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €110.00 | |
5006 | Stem Cell CSD inhibitor Set | Set of CHIR99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. | €140.00 | |
5004 | Stem Cell LSB inhibitor Set | Set of BMP inhibitor LDN 193189 (Axon 1509) and TGF-β inhibitor SB 431542 (Axon 1661) | €90.00 | |
5005 | Stem Cell LSC inhibitor Set | Set of LDN 193189 HCl, SB 431542 and CHIR99021, inhibitors of BMP, TGF-β, and GSK-3 resp. | €130.00 | |
5008 | Stem Cell RG-BIX inhibitor Set | Set of RG 108 and BIX 01294 HCl, inhibitors of DNMT and HMTase, respectively | €60.00 |