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Stem Cell LSB inhibitor Set
Set of 2 Inhibitors
LDN 193189 HCl (Axon 1509)
SB 431542 (Axon 1661)
(2 mg or 5 mg of each inhibitor)
* Two Inhibitors are in powder form (high purity: 99%)
Ready to be reconstituted freshly
to their 10 mM solutions in DMSO respectively.
Expert Recommendation!
Description
A convenient set of BMP inhibitor LDN 193189 hydrochloride (Axon 1509) and TGF-β inhibitor SB 431542 (Axon 1661) (termed as LSB by their name abbreviation), for neural differentiation of human pluripotent stem cells (hPSCs). Dual SMAD inhibition by LSB cocktail is an highly efficient protocol for neural induction of hPSCs and more than 80% of hPSCs can be rapidly induced into Pax6+ neural precursor cells by using LDN 193189 (0.1 µM) and SB 431542 (10 µM).
The LSB protocol can be further extended; with adding CHIR99021 (Axon 1386) to form LSC or LSB/CHIR inhibitor set (Axon 5005) for generating subtype specific neural/neuronal cells; or with combining neuronal 3i (CSD) inhibitor set (Axon 5006) of CHIR99021, SU 5402 (Axon 1667) and DAPT (Axon 1484) to form a 5i inhibitor set (Axon 5007, LSB3i), for rapid differentiation of hPSCs into nociceptors.
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More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | N.A. |
| MFCD | N.A. |
| Short Description | Stem cell inhibitor set |
References
- J. Ladewig et al. Small molecules enable highly efficient neuronal conversion of human fibroblasts. Nat Methods. 2012, 9, 575-578.
- S.M. Chambers et al. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nature Biotechnol. 2012, 30, 715-720.
- S.M. Chambers et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 2009, 27, 275–280.
- List of publications using LDN 193189 (Axon 1509) purchased from Axon Medchem
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