MT-802

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3466

CAS [2231744-29-7]

MF C41H41N9O8
MW 787.82

  • Purity: 97%
  • Soluble in 0.1N HCl(aq) and DMSO
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MT-802

Description

The PROTAC MT-802 is a potent and rapid degrader of BTK with a DC50 value of 9.1 nM with maximal degradation being observed by 250 nM. MT-802 showed IC50 values of 46.9 nM and 20.9 nM for wild-type BTK and C481S BTK, respectively.

KEYWORDS: MT-802 | Supplier | BTK degrader | MT802 | MT 802 | CAS [2231744-29-7] | B-Cell Transformation | BTK | Inhibitor | Enzymes | PROTAC | Chronic lymphocytic leukemia | C481S mutant CLL | B-cell malignancy | Cereblon

Potent and rapid degrader of BTK; PROTAC

Chemical name

2-(2-(2-(4-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)acetamide

Parent CAS No.

[2231744-29-7]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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