THZ531

Based on 12 reference(s) in Google Scholar 8 10 12

Axon 3402

CAS [1702809-17-3]

MF C30H32ClN7O2
MW 558.07

  • Purity: 99%
  • Optical purity: 100% ee
  • Soluble in 0.1N HCl(aq) and DMSO
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THZ531

Description

THZ531 is a first-in-class, potent, selective, covalent inhibitor of CDK12 and CDK13 with IC50 values of 158 nM and 69 nM, respectively.

Keywords: THZ531 | supplier | CDK12/13 inhibitor | THZ 531 | THZ-531 | CAS [1702809-17-3] | [1702809-18-4] | Cyclin Dependent (CDK) | CDK | Inhibitor | Enzymes

First-in-class, potent, selective, covalent CDK12/CDK13 inhibitor

Chemical name

(R,E)-N-(4-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide

Parent CAS No.

[1702809-17-3]

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5 mg €130.00 In Stock
25 mg €460.00 In Stock
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2 x 5 mg €220.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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