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E7449 mesylate
- 2X-121
- Parent CAS: 1140964-99-3
- Soluble in water and DMSO
- MF: C18H15N5O.CH4O3S
- MW: 413.45
Description
E7449 mesylate is a potent, brain penetrable and orally bioavailable dual inhibitor of PARP1/2 and tankyrase1/2, which inhibits growth of DNA repair deficient tumors and antagonizes Wnt signalling. E7449 mesylate exhibits IC50 values of 2.0 and 1.0 nM for PARP1 and PARP2, respectively.
More Information
| Parent CAS No. | 1140964-99-3 |
|---|---|
| Chemical Name | 8-(Isoindolin-2-ylmethyl)-2H-pyridazino[3,4,5-de]quinazolin-3(9H)-one methanesulfonate |
| SMILES | C1C=C2C(=O)NN=C3NC(CN4CC5C=CC=CC=5C4)=NC(=C23)C=1.CS(=O)(O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C18H15N5O.CH4O3S/c24-18-13-6-3-7-14-16(13)17(21-22-18)20-15(19-14)10-23-8-11-4-1-2-5-12(11)9-23;1-5(2,3)4/h1-7H,8-10H2,(H,22,24)(H,19,20,21);1H3,(H,2,3,4) |
| InChiKey | SQQZCNVWIZVPBE-UHFFFAOYSA-N |
| CID | 156600286 |
| Short Description | PARP1/2-TNKS1/2 inhibitor |
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