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ML-9 hydrochloride
- Parent CAS: 110448-31-2
- Soluble in water and DMSO
- MF: C15H17ClN2O2S.HCl
- MW: 361.29
Description
ML-9 hydrochloride is a selective inhibitor of myosin light chain kinase (MLCK). Moreover, ML-9 hydrochloride is an inhibitor of Akt kinase and stromal interaction molecule 1 (STIM1).
More Information
| Parent CAS No. | 110448-31-2 |
|---|---|
| Chemical Name | 1-(5-Chloronaphthalen-1-ylsulfonyl)-1,4-diazepane hydrochloride |
| SMILES | C1C=C2C(S(=O)(=O)N3CCNCCC3)=CC=CC2=C(Cl)C=1.Cl |
| MFCD | MFCD00065525 |
| InChi | InChI=1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H |
| InChiKey | ZNRYCIVTNLZOGI-UHFFFAOYSA-N |
| CID | 108047 |
| Short Description | MLCK/Akt/STIM1 inhibitor |
References
- M Ito et al. Inhibition of natural killer cell-mediated cytotoxicity by ML-9, a selective inhibitor of myosin light chain kinase. Int J Immunopharmacol. 1989;11(2):185-90.
- A Kondratskyi et al. Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death. Cell Death Dis. 2014 Apr 24;5(4):e1193.
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