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Penehyclidine hydrochloride
- Parent CAS: 87827-02-9
- Soluble in water and DMSO
- MF: C20H29NO2.HCl
- MW: 351.91
Description
Penehyclidine hydrochloride is an anticholinergic drug. Penehyclidine hydrochloride had both antimuscarinic and antinicotinic activities and retained potent central and peripheral anticholinerigic activities. The receptor binding assay showed that this compound had far greater selectivity to M3 over M1 receptor subtype, which makes it have potential use in the treatment of respiratory disorders such as chronic obstructive pulmonary disease (COPD).
More Information
| Parent CAS No. | 87827-02-9 |
|---|---|
| Chemical Name | 1-Cyclopentyl-1-phenyl-2-(quinuclidin-3-yloxy)ethanol hydrochloride |
| SMILES | C(COC1C2CCN(CC2)C1)(C1CCCC1)(O)C1C=CC=CC=1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C20H29NO2.ClH/c22-20(18-8-4-5-9-18,17-6-2-1-3-7-17)15-23-19-14-21-12-10-16(19)11-13-21;/h1-3,6-7,16,18-19,22H,4-5,8-15H2;1H |
| InChiKey | DDTVVMRZNVIVQM-UHFFFAOYSA-N |
| CID | 177923 |
| Short Description | Anticholinergic drug |
References
- WZ Niu et al. The effects of a new cholinolytic--8018--and its optical isomers on the central muscarinic and nicotinic receptors. Arch Int Pharmacodyn Ther. 1990;304:64-74.
- YA Wang et al. Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: neurochemical mechanisms. Life Sci 2005 Nov 26;78(2):210-23.
- XY Han e al. Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride (8018). Bioorg Med Chem Lett 2005 Apr 15;15(8):1979-82.
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