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MDL 201012
- Soluble in DMSO
- MF: C19H25NO2
- MW: 299.41
Description
MDL 201012 is a selective M3 muscarinic acetylcholine receptor antagonist with oral antimuscarinic pharmacology.
M3 receptors regulate smooth muscle contraction, glandular secretion and cholinergic signaling in peripheral tissues. MDL 201012 is useful for studying M3 receptor-mediated responses and muscarinic antagonist selectivity.
Key Features
- Selective antagonist of M3 muscarinic receptors
- Orally active antimuscarinic pharmacology
- Modulates cholinergic smooth muscle and secretion pathways
- Small-molecule GPCR antagonist tool
Applications
- M3 receptor pharmacology
- Cholinergic signaling assays
- Smooth muscle contraction studies
- Antimuscarinic selectivity profiling
More Information
| Parent CAS No. | 136722-45-7 |
|---|---|
| Chemical Name | 1-cyclobutyl-7-(dimethylamino)-1-hydroxy-1-phenylhept-5-yn-2-one |
| SMILES | C1C(C(C2C=CC=CC=2)(O)C(=O)CCC#CCN(C)C)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H25NO2/c1-20(2)15-8-4-7-14-18(21)19(22,17-12-9-13-17)16-10-5-3-6-11-16/h3,5-6,10-11,17,22H,7,9,12-15H2,1-2H3 |
| InChiKey | BCOZTAXOTDBLEA-UHFFFAOYSA-N |
| CID | 131987 |
| Short Description | M3 antagonist |
References
- DL Reynolds et al. Determination of MDL 201,012 at femtomole/millilitre levels in human plasma by liquid chromatography with electrochemical detection Biomed Chromatogr. 1992, 6(6), 295-9.
- JP Carter et al. Analogues of oxybutynin. Synthesis and antimuscarinic and bladder activity of some substituted 7-amino-1-hydroxy-5-heptyn-2-ones and related compounds. J. Med. Chem. 1991, 34(10), 3065-74.
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