Bulk Inquiry
VU 0357017 hydrochloride
- Parent CAS: 1135681-23-0
- Soluble in water and DMSO
- MF: C18H27N3O3.HCl
- MW: 369.89
Description
VU 0357017 hydrochloride is a highly selective M1 muscarinic acetylcholine receptor positive allosteric modulator (PAM).
M1 receptor activation is involved in cortical and hippocampal cholinergic signaling, cognition and synaptic plasticity. VU 0357017 is useful for studying M1-selective allosteric potentiation without direct orthosteric agonism.
Key Features
- Selective M1 muscarinic receptor PAM
- Enhances M1 receptor signaling allosterically
- Useful tool for cholinergic GPCR modulation
- Supports cognition-related receptor pharmacology studies
Applications
- M1 receptor pharmacology
- Allosteric GPCR modulator assays
- Cholinergic signaling and cognition models
- Neuroscience drug discovery research
More Information
| Parent CAS No. | 1135681-23-0 |
|---|---|
| Chemical Name | ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate hydrochloride |
| SMILES | C1C(C)=C(C(=O)NCCNC2CCN(C(=O)OCC)CC2)C=CC=1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H |
| InChiKey | XKJQVUIXSBOCPP-UHFFFAOYSA-N |
| CID | 25010775 |
| Short Description | M1 PAM |
References
- EP Lebois et al. Discovery and Characterization of Novel Subtype-Selective Allosteric Agonists for the Investigation of M1 Receptor Function in the Central Nervous System. ACS Chem. Neurosci. 2010, 1(2), 104–121.
- TM Bridges et al. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM. Bioorg. Med. Chem. Lett. 2010, 20(2), 1972-1975.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1109 | Etiracetam |
From $82.50 |
| 1110 | Levetiracetam |
From $93.50 |
| 1111 | UCB-L 060 |
From $132.00 |
| 1273 | Zamifenacin fumarate |
From $143.00 |
| 1289 | GMC 1-109 |
From $137.50 |
| 1483 | VU 0152100 |
From $93.50 |
| 1679 | MDL 201012 |
From $121.00 |
| 1786 | VU 0238429 |
From $115.50 |
| 1787 | VU 0255035 |
From $132.00 |
| 1943 | VU 0365114 |
From $126.50 |
| 1988 | VU 0029767 |
From $121.00 |
| 2049 | Tolterodine L-tartrate |
From $77.00 |
| 2463 | TBPB |
From $115.50 |
| 2587 | ML352 |
From $115.50 |
| 2670 | VU6001221 |
From $137.50 |
| 3271 | VU0486846 |
From $181.50 |
| 3286 | Penehyclidine hydrochloride |
From $143.00 |
| 3505 | Oxybutynin hydrochloride |
From $55.00 |
| 3513 | Bethanechol chloride |
From $55.00 |
| 3648 | Trospium chloride |
From $66.00 |
