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GMC 1-109
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C19H19F3N4O3S
- MW: 440.44
Description
GMC 1-109 is a clozapine analogue with high affinity for the M1 muscarinic acetylcholine receptor (IC50 value of 35 nM).
GMC 1-109 was described as having minimal dopamine, 5-HT2, H1 and α1 adrenergic affinities while retaining M1 affinity. This profile makes it useful for studying muscarinic contributions within clozapine-related CNS pharmacology.
Key Features
- High-affinity M1 muscarinic receptor ligand
- Reported IC50: 35 nM at M1
- Clozapine analogue with reduced DA, 5-HT2, H1 and α1 affinity profile
- Useful for muscarinic CNS pharmacology
Applications
- M1 receptor binding studies
- Clozapine analogue pharmacology
- Muscarinic receptor selectivity profiling
- CNS acetylcholine signaling research
More Information
| Parent CAS No. | 183140-96-7 |
|---|---|
| Chemical Name | 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-yl trifluoromethanesulfonate |
| SMILES | N1C2C=CC=CC=2C(N2CCN(C)CC2)=NC2C=C(OS(C(F)(F)F)(=O)=O)C=CC1=2 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H19F3N4O3S/c1-25-8-10-26(11-9-25)18-14-4-2-3-5-15(14)23-16-7-6-13(12-17(16)24-18)29-30(27,28)19(20,21)22/h2-7,12,23H,8-11H2,1H3 |
| InChiKey | RDPIPNDQCUEYHW-UHFFFAOYSA-N |
| CID | 135515198 |
| Short Description | Clozapine analog |
References
- Y Liao et al. Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J Med Chem. 1997 Dec 5;40(25):4146-53.
- Y Liao et al. New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. J Med Chem. 1999 Jun 17;42(12):2235-44.
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