Bulk Inquiry
GMC 1-161
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C19H22N4O
- MW: 322.4
Description
Analogue of clozapine (Axon 1146); devoid of affinity for the DA D1 receptor, but with affinities at 5-HT2A/2C, hM1 and DA D2 receptors.
More Information
| Parent CAS No. | 95316-97-5 |
|---|---|
| Chemical Name | 2-Methoxy-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine |
| SMILES | N1C2C=CC(OC)=CC=2C(N2CCN(C)CC2)=NC2C=CC=CC1=2 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-13-14(24-2)7-8-16(15)20-17-5-3-4-6-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3 |
| InChiKey | NXWRIBLQJIVCRL-UHFFFAOYSA-N |
| CID | 15521599 |
| Short Description | Clozapine analogue |
References
- Y Liao et al. Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J Med Chem. 1997 Dec 5;40(25):4146-53.
- Y Liao et al. New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. J Med Chem. 1999 Jun 17;42(12):2235-44.
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