Bulk Inquiry
GMC 2-113
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C28H29N5O3
- MW: 483.56
Description
GMC 2-113 is a selective 5-HT1B receptor antagonist with reported selectivity ratios of 5-HT1B (IC50: 6.3 nM) versus 5-HT1D (IC50: 400 nM) up to 63 based on IC50 affinity comparisons. It is useful for distinguishing 5-HT1B-mediated responses.
Selective 5-HT1B antagonists help separate receptor subtype effects within the closely related 5-HT1B/1D family. GMC 2-113 is relevant for serotonin receptor subtype profiling and functional antagonist assays.
Key Features
- Selective 5-HT1B receptor antagonist
- Reported 5-HT1B versus 5-HT1D selectivity ratio up to 63
- Useful for subtype-selective serotonin receptor studies
- Functional antagonist tool compound
Applications
- 5-HT1B receptor pharmacology
- Serotonin receptor subtype selectivity assays
- GPCR antagonist profiling
- Neuronal and vascular serotonergic signaling studies
More Information
| Parent CAS No. | 256227-77-7 |
|---|---|
| Chemical Name | 2'-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-hydroxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide |
| SMILES | N1(C2=CC(=CC=C2O)NC(=O)C2C=CC(=CC=2)C2C(C)=CC(C3OC(C)=NN=3)=CC=2)CCN(C)CC1 |
| MFCD | MFCD10565905 |
| InChi | InChI=1S/C28H29N5O3/c1-18-16-22(28-31-30-19(2)36-28)8-10-24(18)20-4-6-21(7-5-20)27(35)29-23-9-11-26(34)25(17-23)33-14-12-32(3)13-15-33/h4-11,16-17,34H,12-15H2,1-3H3,(H,29,35) |
| InChiKey | NLGSHZDQUKRUEL-UHFFFAOYSA-N |
| CID | 10624680 |
| Short Description | 5-HT1B antagonist |
References
- Y Liao et al. New selective and potent 5-HT1B/1D or 5-HT1B antagonists: chemistry and pharmacological evaluation of GR127935-like compounds. J. Med. Chem. 2000, 43, 517-525.
- JW Clitherow et al. Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzalides as the first selective 5-HT1D antagonists. J. Med. Chem. 1994, 37, 2253.
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