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GR 127935 hydrochloride
- Parent CAS: 148672-13-3
- Soluble in water and DMSO
- MF: C29H31N5O3.HCl
- MW: 534.05
Description
GR 127935 hydrochloride is a putative and selective 5-hydroxytryptamine (5-HT) 1B/1D receptor antagonist. GR 127935 is widely used as a pharmacological tool to investigate the physiological and pathological roles of 5-HT1B and 5-HT1D receptors in central nervous system and peripheral serotonin signaling.
The 5-HT1B and 5-HT1D receptors are G protein-coupled serotonin receptors involved in neurotransmitter release, vascular regulation, pain processing, and migraine pathophysiology. GR 127935 is a valuable research tool for studying serotonergic signaling pathways and receptor-mediated responses.
Key Features
- Putative and selective 5-HT1B/1D antagonist
- Targets serotonin 5-HT1B and 5-HT1D receptors
- Widely used pharmacological research tool
- Useful for serotonergic signaling studies
- Suitable for receptor characterization experiments
Applications
- 5-HT1B and 5-HT1D receptor research
- Serotonin signaling studies
- Neuroscience and neuropharmacology research
- Migraine and pain pathway investigations
- GPCR pharmacology studies
More Information
| Parent CAS No. | 148672-13-3 |
|---|---|
| Chemical Name | N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide hydrochloride |
| SMILES | N1(C2=CC(=CC=C2OC)NC(=O)C2C=CC(=CC=2)C2C(C)=CC(C3N=C(C)ON=3)=CC=2)CCN(C)CC1.Cl |
| MFCD | MFCD08056244 |
| InChi | InChI=1S/C29H31N5O3.ClH/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34;/h5-12,17-18H,13-16H2,1-4H3,(H,31,35);1H |
| InChiKey | SRVVUYIJVBLEJI-UHFFFAOYSA-N |
| CID | 11497466 |
| Short Description | 5-HT1B/1D antagonist |
References
- PJ Pauwels. Pharmacological Properties of a Putative 5-HT1B/D Receptor Antagonist GR 127,935. CNS Drug Reviews 1996, 2(4), 415–428.
- JW Clitherow et al. Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzalides as the first selective 5-HT1D antagonists. J. Med. Chem. 1994, 37, 2253.
- Y Liao et al. New selective and potent 5-HT1B/1D or 5-HT1B antagonists: chemistry and pharmacological evaluation of GR127935-like compounds. J. Med. Chem. 2000, 43, 517-525.
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