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TBPB
- Soluble in DMSO
- MF: C25H32N4O
- MW: 404.55
Description
More Information
| Parent CAS No. | 634616-95-8 |
|---|---|
| Chemical Name | 1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one |
| SMILES | C1(=O)N(C2CCN(C3CCN(CC4=CC=CC=C4C)CC3)CC2)C2=CC=CC=C2N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30) |
| InChiKey | CWPKTBMRVATCBL-UHFFFAOYSA-N |
| CID | 10092649 |
| Short Description | M1 agonist |
References
- C.K. Jones et al. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J Neurosci. 2008 Oct 8;28(41):10422-33. doi: 10.1523/JNEUROSCI.1850-08.2008.
- M.A. Jacobson et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from.... Mol Pharmacol. 2010 Oct;78(4):648-57.
- T.M. Bridges et al. Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5439-42.
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