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cis-(Z)-Flupenthixol dihydrochloride
- (Z)-Flupentixol dihydrochloride
- Parent CAS: 2709-56-0
- Soluble in water, DMSO and EtOH
- MF: C23H25F3N2OS·2HCl
- MW: 507.44
Description
Cis-(Z)-Flupenthixol dihydrochloride is a potent and selective DA receptor antagonist with K values of 0.38 nM and 7 nM for dopamine D2 and 5-HT2A receptors, respectively.
More Information
| Parent CAS No. | 2709-56-0 |
|---|---|
| Chemical Name | 2-(4-((Z)-3-(3-(Trifluoromethyl)-9-thia-10H-anthr-10-ylidene)propyl)-1-piperazinyl)ethanol dihydrochloride |
| SMILES | C1=C2SC3=CC=CC=C3/C(=C/CCN3CCN(CCO)CC3)/C2=CC(C(F)(F)F)=C1.Cl.Cl |
| MFCD | MFCD00069278 |
| InChi | InChI=1S/C23H25F3N2OS.2ClH/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29;;/h1-2,4-8,16,29H,3,9-15H2;2*1H/b18-5-;; |
| InChiKey | IOVDQEIIMOZNNA-MHKBYHAFSA-N |
| CID | 5282483 |
| Short Description | DA antagonist |
References
- P Seeman. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38.
- JM Wenzel et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6.
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