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VU 6008667
Axon 2739
CAS:
2092923-21-0
- Optical Purity: 98% e.e.
- Soluble in DMSO and EtOH
- MF: C24H17ClF2N2O2
- MW: 438.85
Description
VU6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) with IC50 values of 1.2 and 1.6 μM in human and rat M5, respectively. Moreover, VU6008667 has high CNS penetration and shows a desired short half-life in rat (t1/2 = 2.3 h) useful for addiction studies.
More Information
| Parent CAS No. | 2092923-21-0 |
|---|---|
| Chemical Name | (S)-9b-(4-Chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one |
| SMILES | C1C=C2[C@@]3(C4C=C(C)C(Cl)=CC=4)N(C(=O)C4C=CC(F)=C(F)C=4)CCN3C(=O)C2=CC=1 |&1:3,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H17ClF2N2O2/c1-14-12-16(7-8-19(14)25)24-18-5-3-2-4-17(18)23(31)29(24)11-10-28(24)22(30)15-6-9-20(26)21(27)13-15/h2-9,12-13H,10-11H2,1H3/t24-/m0/s1 |
| InChiKey | XMSLRELXMCKGCB-DEOSSOPVSA-N |
| CID | 134824563 |
| Short Description | M5 NAM |
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