Bulk Inquiry
Saracatinib
- AZD0530
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C27H32ClN5O5
- MW: 542.03
Description
An orally bioavailable tyrosine kinase inhibitor, specifically targeting Src and Abl, those kinases often overexpressed in chronic myeloid leukema cells.
Water-soluble form AZD0530 difumarate is available as Axon 1456.
More Information
| Parent CAS No. | 379231-04-6 |
|---|---|
| Chemical Name | N-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-(((4-methylpiperazin-1-yl)methoxy)methyl)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine |
| SMILES | C1C(OC2CCOCC2)=C2C(NC3C4OCOC=4C=CC=3Cl)=NC=NC2=CC=1OCCN1CCN(C)CC1 |
| MFCD | MFCD09832698 |
| InChi | InChI=1S/C27H32ClN5O5/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31) |
| InChiKey | OUKYUETWWIPKQR-UHFFFAOYSA-N |
| CID | 10302451 |
| Short Description | Src-Abl inhibitor |
References
- H Laurent et al. N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. B2517 2006, 49, 6465.
- YM Chang et al. Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene 2008, 1–11.
- PM Gwanmesia et al. The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines. BMC Cancer 2009, 9, 53.
- TP Green et al. Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530. Molecular Oncology 2009, 3(3), 248-261.
- C Dulsat et al. Saracatinib. Drugs Fut. 2009, 34(2), 106.
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