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L651582
- Carboxyamidotriazole - CAI - NSC-609974
- Soluble in DMSO
- MF: C17H12Cl3N5O2
- MW: 424.67
Description
Calcium channel blocker. L651582 inhibits M5 muscarinic receptor-mediated calcium influx and release of arachidonic acid, but has little effect on inositol phosphate or cAMP generation. Antiproliferative and antimetastatic agent.
More Information
| Parent CAS No. | 99519-84-3 |
|---|---|
| Chemical Name | 5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide |
| SMILES | C1(CN2N=NC(C(=O)N)=C2N)C=C(Cl)C(C(C2C=CC(Cl)=CC=2)=O)=C(Cl)C=1 |
| MFCD | MFCD00866325 |
| InChi | InChI=1S/C17H12Cl3N5O2/c18-10-3-1-9(2-4-10)15(26)13-11(19)5-8(6-12(13)20)7-25-16(21)14(17(22)27)23-24-25/h1-6H,7,21H2,(H2,22,27) |
| InChiKey | WNRZHQBJSXRYJK-UHFFFAOYSA-N |
| CID | 108144 |
| Short Description | Ca channel blocker |
References
- EC Kohn et al. L651582: a novel antiproliferative and antimetastasis agent. J Natl Cancer Inst. 1990 Jan 3;82(1):54-60.
- CC Felder et al. The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J Pharmacol Exp Ther. 1991 Jun;257(3):967-71.
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