SR-4835

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 3184

CAS [2387704-62-1]

MF C21H20Cl2N10O
MW 499.36

  • Purity: 99%
  • Soluble in DMSO
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SR-4835

Description

SR-4835 is a potent, highly selective and orally bioavailable dual inhibitor of CDK12 and CDK13 (IC50 value of 99 nM for CDK12; Kd values of 98 and 4.9 nM for CDK12 and CDK13, respectively). SR-4835 has potent cell-based and in vivo anti-triple-negative breast cancer (TNBC) activity and augments the anti-cancer activity of cisplatin, irinotecan, and olaparib, which are standard-of-care therapeutics for TNBC.

KEYWORDS: SR-4835 | supplier | CDK12/13 inhibitor | SR 4835 | SR4835 | CAS [2387704-62-1] | Cyclin Dependent (CDK) | CDK | Inhibitor | Enzymes | Triple-negative breast cancer | TNBC

Potent, highly selective and orally bioavailable dual CDK12/CDK13 inhibitor

Chemical name

N-((5,6-Dichloro-1H-benzo[d]imidazol-2-yl)methyl)-9-(1-methyl-1H-pyrazol-4-yl)-2-morpholino-9H-purin-6-amine

Parent CAS No.

[2387704-62-1]

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5 mg €130.00 In Stock
25 mg €460.00 In Stock
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2 x 5 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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