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SR-4835
- Soluble in DMSO
- MF: C21H20Cl2N10O
- MW: 499.36
Description
SR-4835 is a potent, highly selective and orally bioavailable dual inhibitor of CDK12 and CDK13 (IC50 value of 99 nM for CDK12; Kd values of 98 and 4.9 nM for CDK12 and CDK13, respectively). SR-4835 has potent cell-based and in vivo anti-triple-negative breast cancer (TNBC) activity and augments the anti-cancer activity of cisplatin, irinotecan, and olaparib, which are standard-of-care therapeutics for TNBC.
More Information
| Parent CAS No. | 2387704-62-1 |
|---|---|
| Chemical Name | N-((5,6-Dichloro-1H-benzo[d]imidazol-2-yl)methyl)-9-(1-methyl-1H-pyrazol-4-yl)-2-morpholino-9H-purin-6-amine |
| SMILES | C1(NCC2NC3C=C(Cl)C(Cl)=CC=3N=2)C2N=CN(C3=CN(C)N=C3)C=2N=C(N2CCOCC2)N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H20Cl2N10O/c1-31-10-12(8-26-31)33-11-25-18-19(29-21(30-20(18)33)32-2-4-34-5-3-32)24-9-17-27-15-6-13(22)14(23)7-16(15)28-17/h6-8,10-11H,2-5,9H2,1H3,(H,27,28)(H,24,29,30) |
| InChiKey | FSELUFUYNUNZKD-UHFFFAOYSA-N |
| CID | 139600338 |
| Short Description | CDK12/13 inhibitor |
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